The cardinals are shut off from the world for the secretive voting that will result in new leadership for the world's 1.4 billion Roman Catholics.

One hundred thirty three cardinals will gather again on Thursday under the vaulted ceilings of the Sistine Chapel, which are decorated with Michelangelo's frescoes, including "The Creation of Adam," where they'll cast their second set of ballots to make one among them the next leader of the Catholic Church's more than 1 billion members worldwide.